A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis
Ting Ge, Weiwei Zhang, Fei Ge, Longbao Zhu, Ping Song, Wanzheng Li, Lin Gui, Dong Wan, Yugui Tao, Kai Yang
Abstract
, displaying a better efficacy of combined chemotherapy and photothermal therapy. Experiments conducted on the 5-Fu/ICG@ZIF-90-PEG-ZOL nanoparticles demonstrated their promising performance for cancer bone metastasis inhibition.
Topics & Concepts
Photothermal therapyDrug deliveryIn vivoCancer cellBone metastasisIndocyanine greenBisphosphonateCancer researchChemistryApoptosisMetastasisZoledronic acidChemotherapyCancerCytotoxicityIn vitroMedicineMaterials sciencePathologyNanotechnologyOncologyInternal medicineBiochemistryOsteoporosisBiologyBiotechnologyOrganic chemistryNanoplatforms for cancer theranosticsBone health and treatmentsMetal-Organic Frameworks: Synthesis and Applications