SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline
Tuomas O. Lilius, Marko Rosenholm, Laura Klinger, Kristian Nygaard Mortensen, Björn Sigurðsson, Frida Lind‐Holm Mogensen, Natalie Hauglund, Malthe Skytte Nordentoft Nielsen, Tomi Rantamäki, Maiken Nedergaard
Abstract
Tc-DTPA. In sum, SPECT/CT imaging presents a valuable approach to study glymphatic drug delivery. Using this methodology, we show that systemic HTS increases intracranial availability of cerebrospinal fluid-administered tracer, but has marginal effects on brain clearance, thus substantiating a simple, yet effective strategy for enhancing intrathecal drug delivery to the brain.
Topics & Concepts
Glymphatic systemCerebrospinal fluidHypertonic salinePathologyTonicityMedicineNeuroscienceAnesthesiaPsychologyInternal medicineCerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular DisturbancesFetal and Pediatric Neurological Disorders