Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone
Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan, Eric Chun Yong Chan
Topics & Concepts
ChemistryBenzbromaroneGlutathioneCytochrome P450StereochemistryCYP3A4Reactive intermediateHemeMetaboliteUricosuricBiochemistryEnzymeCatalysisHyperuricemiaUric acidPharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and ProtectionEicosanoids and Hypertension Pharmacology