Harnessing the power of IFN for therapeutic approaches to COVID-19
Elise G. Viox, Steven E. Bosinger, Daniel C. Douek, Gideon Schreiber, Mirko Paiardini
Abstract
Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.
Topics & Concepts
BiologyCoronavirus disease 2019 (COVID-19)Virology2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BetacoronavirusComputational biologyPandemicPower (physics)OutbreakInfectious disease (medical specialty)Internal medicineDiseaseQuantum mechanicsMedicinePhysicsSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesPhagocytosis and Immune Regulation