Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones
Jidan Liu, Zhenke Yang, Jinyuan Jiang, Qiaohai Zeng, Liyao Zheng, Zhao‐Qing Liu
Abstract
The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.
Topics & Concepts
ChemistryBifunctionalNucleophileOxazolineBond cleavageCatalysisCleavage (geology)RhodiumOxidative phosphorylationCombinatorial chemistryMedicinal chemistryOrganic chemistryBiochemistryEngineeringFracture (geology)Geotechnical engineeringSynthesis and pharmacology of benzodiazepine derivativesCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions