Copper-promoted cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines using a peroxide-driven radical reductive strategy
Huimin Jiang, Jing‐Hao Qin, Qing Sun, Dong Zhang, Jin-Peng Jiang, Xuan‐Hui Ouyang, Ren‐Jie Song, Jin‐Heng Li
Abstract
Direct radical-mediated reductive coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines to build the C(sp 3 )–N bond using 4-alkyl-1,4-dihydropyridines as internal reducing agents and alkyl sources is presented.
Topics & Concepts
ChemistryAlkylCoupling (piping)PeroxideCopperCombinatorial chemistryCoupling reactionMedicinal chemistryOrganic chemistryCatalysisMetallurgyMaterials scienceCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions