Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis
Yuqin Di, Xiaolin Han, Xin-Le Kang, Di Wang, Caihua Chen, Jin‐Xing Wang, Xiao‐Fan Zhao
Abstract
epidermal cell line; HE staining: hematoxylin and eosin staining; IgG: immunoglobin G; IM: imaginal midgut; JH: juvenile hormone; Kr-h1: krueppel homologous protein 1; LM: larval midgut; M6P: mannose-6-phosphate; PBS: phosphate-buffered saline; PCD: programmed cell death; PNGase: peptide-N-glycosidase F; RFP: red fluorescent protein; RNAi: RNA interference; SDS-PAGE: sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SYX17: syntaxin 17; USP1: ultraspiracle isoform 1.
Topics & Concepts
Cathepsin DBiologyAutophagyCell biologyApoptosisCathepsinProteaseEnzymeBiochemistryMosquito-borne diseases and controlInsect Resistance and GeneticsInvertebrate Immune Response Mechanisms