Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M
Ho Shin Kim, Jared T. Hammill, Daniel C. Scott, Yizhe Chen, Amy L. Rice, William Pistel, Bhuvanesh Singh, Brenda A. Schulman, R. Kiplin Guy
Abstract
for 24 h in mice.
Topics & Concepts
NeddylationNEDD8ChemistryCullinBioavailabilityUbiquitinIn vivoPharmacokineticsPharmacologyBiochemistryUbiquitin ligaseBiologyBiotechnologyGeneUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysAutophagy in Disease and Therapy