Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics
Kulkaew Sukniam, Harsheen Kaur Manaise, Kyle Popp, Reed Popp, Emmanuel Gabriel
Abstract
We aimed to review the molecular characteristics of metastatic melanoma and the role of surgery in metastasectomy for metastatic melanoma. We performed a systematic literature search on PubMed to identify relevant studies focusing on several mutations, including NRAS, BRAF, NF1, MITF, PTEN, TP53, CDKN2A, TERT, TMB, EGFR, and c-KIT. This was performed in the context of metastatic melanoma and the role of metastasectomy in the metastatic melanoma population. A comprehensive review of these molecular characteristics is presented with a focus on their prognosis and role in surgical metastasectomy.
Topics & Concepts
MetastasectomyMedicineMelanomaMetastatic melanomaContext (archaeology)Neuroblastoma RAS viral oncogene homologPTENOncologyMicrophthalmia-associated transcription factorCDKN2APopulationInternal medicineDermatologyCancer researchMetastasisCancerPI3K/AKT/mTOR pathwayKRASColorectal cancerBiologyApoptosisPaleontologyTyrosinaseEnzymeBiochemistryEnvironmental healthMelanoma and MAPK PathwaysCutaneous Melanoma Detection and ManagementCAR-T cell therapy research