Design, synthesis, in vitro and in silico studies of some novel triazoles as anticancer agents for breast cancer
Derya Osmani̇ye, Begüm Nurpelin Sağlık, Serkan Levent, Sinem Ilgın, Yusuf Özkay, Zafer Asım Kaplancıklı
Topics & Concepts
ChemistryAromataseMTT assayCytotoxicityViability assayDocking (animal)In vitroIn silicoCell cultureStereochemistryEnzymeIC50MCF-7Aromatase inhibitorBreast cancerPharmacologyBiochemistryCancerHuman breastInternal medicineBiologyMedicineGeneGeneticsNursingSynthesis and biological activityEstrogen and related hormone effectsCancer therapeutics and mechanisms