Discovery of new polymorphs of the tuberculosis drug isoniazid
Keke Zhang, Noalle Fellah, Alexander G. Shtukenberg, Xiaoyan Fu, Chunhua Hu, Michael D. Ward
Abstract
Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement.
Topics & Concepts
IsoniazidMetastabilityTuberculosisCrystallizationMaterials scienceDrugMedicineChemistryPharmacologyOrganic chemistryPathologyCrystallization and Solubility StudiesCrystallography and molecular interactionsX-ray Diffraction in Crystallography