Nickel‐Catalyzed Regioselective Alkenylarylation of γ,δ‐Alkenyl Ketones via Carbonyl Coordination
Roshan K. Dhungana, Vivek Aryal, Doleshwar Niroula, Rishi R. Sapkota, Margaret G. Lakomy, Ramesh Giri
Abstract
Abstract We disclose a nickel‐catalyzed reaction, which enabled us to difunctionalize unactivated γ,δ‐alkenes in ketones with alkenyl triflates and arylboronic esters. The reaction was made feasible by the use of 5‐chloro‐8‐hydroxyquinoline as a ligand along with NiBr 2 ⋅DME as a catalyst and LiO t Bu as base. The reaction proceeded with a wide range of cyclic, acyclic, endocyclic and exocyclic alkenyl ketones, and electron‐rich and electron‐deficient arylboronate esters. The reaction also worked with both cyclic and acyclic alkenyl triflates. Control experiments indicate that carbonyl coordination is required for the reaction to proceed.
Topics & Concepts
ChemistryRegioselectivityCatalysisNickelLigand (biochemistry)Medicinal chemistryKetoneReaction conditionsCombinatorial chemistryOrganic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms