Cognitive impairment appears progressive in the mdx mouse
Emine Bagdatlioglu, Paola Porcari, Elizabeth Greally, Andrew M. Blamire, Volker Straub
Abstract
- relaxometry which may be considered as evidence of increased water content. Hippocampal spatial learning and memory was decreased in mdx mice, particularly long-term memory, which progressively worsened with age. The novel object recognition (NOR) task highlighted elevated anxiety-related behaviour in older mdx mice. Our studies suggest that dystrophin deficiency causes a progressive cognitive impairment in mice (compared to ageing control mice), becoming evident at late disease stages, and may explain why progressive CNS symptoms are not obvious in DMD patients.
Topics & Concepts
Dystrophinmdx mouseDuchenne muscular dystrophyHippocampusPutamenNeuroscienceMedicinePsychologyCognitive declineHippocampal formationLateral ventriclesInternal medicinePathologyEndocrinologyDementiaDiseaseMuscle Physiology and DisordersAdipose Tissue and MetabolismMitochondrial Function and Pathology