The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and <i>in silico</i> mechanistic studies as dual DNA gyrase and DHFR inhibitors
Mohamed H. El‐Shershaby, Kamal M. El‐Gamal, Ashraf H. Bayoumi, Khaled El‐Adl, Mohamed Alswah, Hany E. A. Ahmed, Ahmed A. Al‐Karmalawy, Hamada S. Abulkhair
Abstract
The resistance of pathogenic microbes to currently available antimicrobial agents has been considered a global alarming concern.
Topics & Concepts
ChemistryDNA gyraseIn silicoQuinolineAntimicrobialPharmacokineticsQuinoloneCombinatorial chemistryPharmacologyComputational biologyStereochemistryBiochemistryAntibioticsEscherichia coliOrganic chemistryBiologyMedicineGeneCancer therapeutics and mechanismsSynthesis and Biological EvaluationSynthesis and biological activity