The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses
Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R. Groom, Colby Zaph, Kim L. Good‐Jacobson
Abstract
mice, class-switched antibody-secreting cells are significantly attenuated and germinal centers fail to form. Consequently, DOT1L is essential for B cell memory formation. Transcriptome, pathway, and histological analyses identified a role for DOT1L in reprogramming gene expression for appropriate localization of B cells during the initial stage of the response. Together, these results demonstrate an essential role for DOT1L in generating an effective humoral immune response.
Topics & Concepts
Immune systemBiologyGerminal centerReprogrammingGene silencingEpigeneticsHistone methyltransferaseCell biologyB cellHistoneHistone H3ImmunologyAntibodyCellGeneGeneticsEpigenetics and DNA MethylationImmune Cell Function and InteractionCAR-T cell therapy research