Modeling membranes in situ
Chelsea M. Brown, Siewert J. Marrink
Abstract
Molecular dynamics simulations of cellular membranes have come a long way-from simple model lipid bilayers to multicomponent systems capturing the crowded and complex nature of real cell membranes. In this opinionated minireview, we discuss the current challenge to simulate the dynamics of membranes in their native environment, in situ, with the prospect of reaching the level of whole cells and cell organelles using an integrative modeling framework.
Topics & Concepts
In situMembraneChemistryComputational biologyBiophysicsBiologyBiochemistryOrganic chemistryLipid Membrane Structure and BehaviorCellular transport and secretionNanopore and Nanochannel Transport Studies