Cancer photocytotoxicity and anti-inflammatory response of <i>cis</i>-A<sub>2</sub>B<sub>2</sub> type <i>meso-p</i>-nitrophenyl and <i>p</i>-hydroxyphenyl porphyrin and its zinc(<scp>ii</scp>) complex: a synthetic alternative to the THPP synthon
Debdulal Sharma, Zeaul H. Mazumder, Devashish Sengupta, Avinaba Mukherjee, Mahuya Sengupta, Ranjan Kumar Das, Monjur Hassan Barbhuiya, Partha Palit, Tarun Jha
Abstract
In comparison with the popular synthetic synthon THPP, the <italic>cis</italic>-A<sub>2</sub>B<sub>2</sub> type of porphyrin derivative and its zinc(<sc>ii</sc>) complex PN<sub>2</sub>(OH)<sub>2</sub>Zn offer more promising photochemical and photobiological outcomes.
Topics & Concepts
ChemistryPorphyrinSynthonZincDerivative (finance)PhotosensitizerStereochemistryMedicinal chemistryPhotochemistryOrganic chemistryEconomicsFinancial economicsNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research Studies