Enhancing curcumin's solubility and antibiofilm activity<i>via</i>silica surface modification
Caio H. N. Barros, Henry Devlin, Dishon Hiebner, Stefania Vitale, Laura Quinn, Eoin Casey
Abstract
. Cell viability of sessile cells in both cases was also considerably affected, which is not observed for curcumin delivered as a free compound at the same concentration. Furthermore, proteomics of extracted EPS matrix of biofilms grown in the presence of free curcumin and curc-NPs revealed differences in the expression of key proteins related to cell detoxification and energy production. Therefore, curc-NPs are presented here as an alternative for curcumin delivery that can be exploited not only to other bacterial strains but also to further biological applications.
Topics & Concepts
BiofilmCurcuminNanocarriersAntimicrobialChemistryExtracellular polymeric substanceMesoporous silicaSolubilityRhamnolipidMicrobiologyDrug deliveryBacteriaBiophysicsPseudomonas aeruginosaBiochemistryOrganic chemistryMesoporous materialBiologyGeneticsCatalysisOral microbiology and periodontitis researchBacterial biofilms and quorum sensingAntimicrobial Peptides and Activities