Hypertriglyceridemia‐modulated gut microbiota promotes lysophosphatidylcholine generation to aggravate acute pancreatitis in a TLR4‐dependent manner
Xiaofan Song, Lei Qiao, Xina Dou, Jiajing Chang, Xiaonan Zeng, Tianjing Deng, Ge Yang, Peiyun Liu, Cheng Wang, Qinhong Xu, Chunlan Xu
Abstract
Hypertriglyceridemia (HTG) can lead to the disorder of gut microbiota in mice, resulting in the increase of endotoxin content. HTG can also aggravate the damage of intestinal barrier function and intestinal bacterial translocation in acute pancreatitis (AP) mice. Toll-like receptor 4 gene (Tlr4) knockout can significantly reduce gut permeability and endotoxin invasion in AP mice. In addition, HTG-modulated gut microbiota could up-regulate glycerophospholipid metabolism and increase lysophosphatidylcholine (LysoPC) content in a TLR4-dependent manner, thereby aggravating pancreatic injury in AP.
Topics & Concepts
LysophosphatidylcholineHypertriglyceridemiaTLR4Acute pancreatitisPancreatitisMedicineGut floraInternal medicineImmunologyBiologyInflammationBiochemistryTriglyceridePhosphatidylcholinePhospholipidCholesterolMembranePancreatitis Pathology and TreatmentPancreatic and Hepatic Oncology ResearchLipid metabolism and disorders