Low-density lipoprotein receptor-related protein 6 regulates cardiomyocyte-derived paracrine signaling to ameliorate cardiac fibrosis
Xiang Wang, Yan Zou, Zhidan Chen, Yang Li, Le Pan, Ying Wang, Ming Liu, Chao Yin, Jian Wu, Chunjie Yang, Lei Zhang, Chenze Li, Zheyong Huang, Dao Wen Wang, Juying Qian, Junbo Ge, Yunzeng Zou, Hui Gong
Abstract
Cardiomyocyte-expressed LRP6 promoted the degradation of Wnt5a and Wnt11 by regulating CTSD and inhibited cardiac fibrosis under pressure overload. Our study demonstrated a novel role of LRP6 as an anti-fibrosis regulator.
Topics & Concepts
Paracrine signallingFibrosisReceptorCardiac fibrosisCell biologySignal transductionMedicineLipoproteinInternal medicineCardiologyEndocrinologyCancer researchChemistryBiologyCholesterolCardiac Fibrosis and RemodelingWnt/β-catenin signaling in development and cancerCardiomyopathy and Myosin Studies