Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD
Alia Ghrayeb, Alexandra C Finney, Bella Agranovich, Daniel Peled, Sumit Kumar Anand, M. Peyton McKinney, Mahasen Sarji, Dongshan Yang, Natan Weissman, Shani Drucker, Sara Fernandes, Jonatan Fernández-García, K. Mahan, Zaid Abassi, Lin Tan, Philip L. Lorenzi, James Traylor, Jifeng Zhang, Ifat Abramovich, Yujie Chen, Oren Rom, Inbal Mor, Eyal Gottlieb
Topics & Concepts
SerineAcetaminophenGlycineChemistryPharmacologyBiochemistryBiologyAmino acidEnzymeLiver Disease Diagnosis and TreatmentLiver physiology and pathologyHepatitis B Virus Studies