Forging the Tetracyclic Core Framework of Rhodomolleins XIV and XLII: A Ring-Distortion Approach
Zhen‐Ning Yang, Huijuanzi Rao, Yuhao Yin, Shan Mu, Ziqi Jia, Hanfeng Ding
Abstract
A ring distortion approach for the synthesis of an advanced intermediate en route to rhodomolleins XIV and XLII was described, which led to successful construction of the 5/8/5/5 tetracyclic core framework of the kalmane diterpenoids. Key steps of the strategy include an oxidative dearomatization-induced (ODI)-Diels-Alder cycloaddition, a Dowd-Beckwith rearrangement, and a bioinspired Wagner-Meerwein rearrangement.
Topics & Concepts
ChemistryCore (optical fiber)Distortion (music)Ring (chemistry)StereochemistryCombinatorial chemistryCrystallographyNanotechnologyTelecommunicationsOrganic chemistryComputer scienceMaterials scienceBandwidth (computing)AmplifierMarine Sponges and Natural ProductsBioactive Natural Diterpenoids ResearchCancer Treatment and Pharmacology