Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation
Ana Tapia‐Abellán, Diego Angosto-Bazarra, Cristina Alarcón‐Vila, María C. Baños, Iva Hafner‐Bratkovič, Baldomero Oliva, Pablo Pelegrı́n
Abstract
efflux–specific NLRP3 activators and promoted an in vivo inflammatory response to uric acid crystals. Our results establish that the amino-terminal sequence between PYD and NACHT domain of NLRP3 is key for inflammasome activation.
Topics & Concepts
InflammasomeLinkerIntracellularEffluxPyrin domainChemistryBiophysicsIn vivoCell biologyReceptorBiochemistryBiologyGeneticsOperating systemComputer scienceInflammasome and immune disordersGout, Hyperuricemia, Uric AcidIon Channels and Receptors