Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis
Xiaogang Wang, Qianyu Chen, Ziqian Bing, Shizhen Zhou, Zhen Xu, Yayi Hou, Yue Zhao, Shuli Zhao, Tingting Wang
Abstract
Our findings unveil YTHDC1 as a tumor suppressor in the progression of ovarian cancer and as a potential prognostic biomarker that could serve as a target in ovarian cancer treatment.
Topics & Concepts
Chromatin immunoprecipitationOvarian cancerBiologyCancer researchImmunoprecipitationSTAT3Western blotMolecular biologyCancerPromoterGene expressionCell biologySignal transductionGeneGeneticsRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research