Cobalt‐Catalyzed α‐Arylation of Substituted α‐Bromo α‐Fluoro β‐Lactams with Diaryl Zinc Reagents: Generalization to Functionalized Bromo Derivatives
Mélanie M. Lorion, Vanessa Koch, Martin Nieger, H.-H. Chen, Aiwen Lei, Stefan Bräse, Janine Cossy
Abstract
A cobalt-catalyzed cross-coupling of α-bromo α-fluoro β-lactams with diarylzinc or diallylzinc reagents is herein disclosed. The protocol proved to be general, chemoselective and operationally simple allowing the C4 functionalization of β-lactams. The substrate scope was expanded to α-bromo lactams and amides, α-bromo lactones and esters as well as N- and O-containing heterocycles.
Topics & Concepts
ReagentCobaltCatalysisCombinatorial chemistryZincSubstrate (aquarium)ChemistrySurface modificationOrganic chemistryGeologyPhysical chemistryOceanographyFluorine in Organic ChemistrySynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms