Supratentorial ependymoma with <scp><i>YAP1:FAM118B</i></scp> fusion: A case report
Jian Wang, Liang Wang, Lin Fu, Qingchang Li, Xue-shan Qiu, En‐Hua Wang, Juan‐Han Yu
Abstract
We report a case of a 26‐year‐old Chinese man who had experienced three grand mal seizures in the past two months. Magnetic resonance imaging revealed a relatively well‐circumscribed lesion in the left frontal lobe. A craniotomy with total excision of the tumor was performed. Histopathological investigations confirmed a grade 2 ependymoma according to the World Health Organization classification. Genetic analysis revealed a tumor harboring FAM118B fusion to YAP1 , and no other genetic alterations or methylation of the O 6 ‐methylguanine‐DNA methyltransferase gene promoter were detected. This is the second case report of ependymoma with YAP1:FAM118B fusion.
Topics & Concepts
EpendymomaMagnetic resonance imagingLesionMedicineMedulloblastomaPathologyRadiologyAdvanced Neural Network ApplicationsRenal and related cancersCancer Genomics and Diagnostics