Divergent properties and independent regulation of striatal dopamine and GABA co-transmission
Sarah M. Zych, Christopher Ford
Abstract
sensitivity, release probability, and requirement of active zone scaffolding proteins, differ between the two transmitters. Moreover, the extent by which presynaptic neuromodulators inhibit co-transmission also varied. Differences in modulation and the mechanisms controlling release allow for independent regulation of dopamine and GABA signals despite both being loaded via similar mechanisms.
Topics & Concepts
DopamineMedium spiny neuronSubstantia nigraNeurotransmissionStriatumNeurotransmitterNeuroscienceInhibitory postsynaptic potentialBasal gangliaPars compactaChemistryGABAA receptorVesicular monoamine transporterMonoamine neurotransmitterBiologyReceptorDopaminergicBiochemistrySerotoninCentral nervous systemNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling