An engineered three-dimensional stem cell niche in the inner ear by applying a nanofibrillar cellulose hydrogel with a sustained-release neurotrophic factor delivery system
Hsiang-Tsun Chang, Rachel A. Heuer, Andrew M. Oleksijew, Kyle S. Coots, Christian B. Roque, Kevin T. Nella, Tammy L. McGuire, Akihiro J. Matsuoka
Topics & Concepts
Materials scienceInner earCelluloseNicheBrain-derived neurotrophic factorNeurotrophic factorsStem cellTissue engineeringSelf-healing hydrogelsBiomedical engineeringNanotechnologyChemical engineeringPolymer chemistryNeuroscienceCell biologyChemistryEngineeringBiologyBiochemistryReceptorNerve injury and regenerationNeurogenesis and neuroplasticity mechanismsElectrospun Nanofibers in Biomedical Applications