Mathematical model of brain tumour growth with drug resistance
Iarosz, Kelly C.
2021LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)26 citationsDOIOpen Access PDF
Abstract
Brain tumours are masses of abnormal cells that can grow in an uncontrolled way in the brain. There are different types of malignant brain tumours. Gliomas are malignant brain tumours that grow from glial cells and are identified as astrocytoma, oligodendroglioma, and ependymoma. We study a mathematical model that describes glia-neuron interaction, glioma, and chemotherapeutic agent. In this work, we consider drug sensitive and resistant glioma cells. We show how continuous and pulsed chemotherapy can kill glioma cells with a minimal loss of neurons.
Topics & Concepts
Resistance (ecology)Growth modelDrug resistanceComputer scienceMathematicsNeuroscienceBiologyMathematical economicsGeneticsEcologyMathematical Biology Tumor GrowthGlioma Diagnosis and TreatmentMicrotubule and mitosis dynamics