<i>In vivo</i> molecular imaging of breast cancer metabolic heterogeneity using [1- <sup>13</sup> C]pyruvate-d <sub>3</sub> hyperpolarized by reversible exchange with parahydrogen
Stefan Petersen, Luca Nagel, Philipp Groß, Henri de Maissin, Robert Willing, Lisa Heß, Julia Mitschke, Nicole Klemm, Judith Treiber, Christoph Müller, Stephan Knecht, Ilai Schwartz, Moritz Weigt, Michael Bock, Dominik von Elverfeldt, Maxim Zaitsev, Eduard Y. Chekmenev, Jan‐Bernd Hövener, André F. Martins, Franz Schilling, Thomas Reinheckel, Andreas B. Schmidt
Abstract
Our results underscore the potential of SABRE to enhance the accessibility and throughput of HP MRI, thereby advancing cancer research and diagnostic oncology.
Topics & Concepts
In vivoMolecular imagingBreast cancerPKM2Spin isomers of hydrogenChemistryHyperpolarization (physics)CancerRadiochemistryNuclear magnetic resonanceMetabolismPyruvate kinaseMedicineBiochemistryGlycolysisBiologyNuclear magnetic resonance spectroscopyPhysicsInternal medicineStereochemistryHydrogenGeneticsOrganic chemistryAdvanced NMR Techniques and ApplicationsEnzyme Structure and FunctionInorganic Fluorides and Related Compounds