Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery
Savan K. Patel, Margaret M. Billingsley, Alvin J. Mukalel, Ajay S. Thatte, Alex G. Hamilton, Ningqiang Gong, Rakan El‐Mayta, Hannah C. Safford, Maria Merolle, Michael J. Mitchell
Abstract
These results demonstrate the potential of a four-component BA-LNP formulation, CA-100, for extrahepatic mRNA delivery that could potentially be utilized for a range of therapeutic and vaccine applications.
Topics & Concepts
Cholic acidChenodeoxycholic acidBile acidLithocholic acidCholesterolDeoxycholic acidIn vivoChemistryGene deliveryBiochemistryTransfectionBiologyBiotechnologyGeneRNA Interference and Gene DeliveryHepatitis B Virus StudiesDrug Transport and Resistance Mechanisms