Gold-Catalyzed 1,2-Aminoarylation of Alkenes with External Amines
Akash G. Tathe, Urvashi Urvashi, Amit Kumar Yadav, Chetan C. Chintawar, Nitin T. Patil
Abstract
Reported herein is the gold-catalyzed 1,2-aminoarylation of alkenes that engages external amine as a coupling partner. Careful optimization studies revealed a significant role of the concentration of base to achieve highly chemoselective access to the aminoarylation products over potential C–N cross-coupled products. Overcoming all the limitations, the current strategy provided straightforward access to the medicinally relevant 3-aminochroman, 2-aminotetrahydronaphthalene, and 2-aminoindane derivatives.
Topics & Concepts
CatalysisAmine gas treatingCombinatorial chemistryChemistryBase (topology)Organic chemistryMathematicsMathematical analysisCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions