Chiral oxamide–phosphine–palladium catalyzed highly asymmetric allylic amination: carbonyl assistance for high regio- and enantiocontrols
Jun‐Bo Chen, Cheng Peng, Sheng‐Suo Zhou, Yong Wang, Zheng Wang, Xing‐Wang Wang
Abstract
The chiral oxamide–phosphine (COAP) ligands were developed for the palladium-catalyzed asymmetric allylic amination of vinyl benzoxazinones with alkylamines, affording a series of optically active diamines in good yields with high enantioselectivity.
Topics & Concepts
ChemistryAminationPhosphineAllylic rearrangementPalladiumOxamideCatalysisOrganic chemistryOptically activeCombinatorial chemistryMedicinal chemistryAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions