Successful Tepotinib Challenge After Capmatinib-Induced Interstitial Lung Disease in a Patient With Lung Adenocarcinoma Harboring MET Exon 14 Skipping Mutation: Case Report
Mizuha Hashiguchi, Takashi Sato, Hiroki Yamamoto, Rinako Watanabe, Junko Kagyo, Hideharu Domoto, Tetsuya Shiomi
Abstract
MET tyrosine kinase inhibitors, capmatinib and tepotinib, have been recently introduced for the treatment of advanced NSCLC with MET exon 14 skipping mutations. Although interstitial lung disease (ILD) induced by these drugs is reported, its optimal management and whether they can be rechallenged remain unclear. We report the first successful case of tepotinib treatment after capmatinib-induced ILD. Switching MET tyrosine kinase inhibitors after drug-induced ILD could be a clinical option, which warrants further investigation.
Topics & Concepts
MedicineInterstitial lung diseaseExonLung cancerTyrosine-kinase inhibitorLungProtein-Tyrosine KinasesMutationAdenocarcinomaTyrosine kinaseOncologyInternal medicineAdenocarcinoma of the lungCancer researchBioinformaticsCancerGeneGeneticsReceptorBiologyLung Cancer Treatments and MutationsInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisPI3K/AKT/mTOR signaling in cancer