α-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate
Meir Schechter, Merav Atias, Suaad Abd Elhadi, Dana Davidi, Daniel Gitler, Ronit Sharon
Abstract
levels, however, with the exception of the A30P mutation. This study provides evidence for a critical involvement of PIPs in α-Syn-mediated membrane trafficking.
Topics & Concepts
EndocytosisPhosphatidylinositol 4,5-bisphosphateCell biologyExocytosisPhosphatidylinositolBiologyClathrinReceptor-mediated endocytosisBiochemistrySignal transductionReceptorMembraneCellular transport and secretionParkinson's Disease Mechanisms and TreatmentsLipid Membrane Structure and Behavior