Urease of Aspergillus fumigatus Is Required for Survival in Macrophages and Virulence
Zhenzhen Xiong, Nan Zhang, Liru Xu, Zhiduo Deng, Jarukitt Limwachiranon, Yaojie Guo, Yi Han, Wei Yang, Daniel H. Scharf
Abstract
The development of antifungal drugs is an urgent task, but it has proven to be difficult due to many similarities between fungal and animal cells. Here, we characterized the urease system in A. fumigatus , which depends on nickel for activity.
Topics & Concepts
Aspergillus fumigatusVirulenceUreaseMicrobiologyPhagosomeBiologyCryptococcus neoformansVirulence factorEnzymeBiochemistryPhagocytosisGeneAntifungal resistance and susceptibilityFungal Infections and StudiesPeptidase Inhibition and Analysis