SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection
Yue Qu, Aline Haas de Mello, Dorothea R. Morris, Yava Jones‐Hall, Teodora Ivanciuc, Rachel A. Sattler, Slobodan Paessler, Vineet D. Menachery, Robert Garofalo, Antonella Casola
Abstract
gene show increased clinical signs of disease and lung pathology when infected with a mouse-adapted strain of SARS-CoV-2. Overall, this study provides a mechanistic explanation for the observed unbalanced pro-oxidative response in SARS-CoV-2 infections and suggests that therapeutic strategies for COVID-19 may consider the use of pharmacologic agents that are known to boost the expression levels of cellular NRF2.
Topics & Concepts
Respiratory tractAntioxidantLungAirwayOxidative stressImmunologyBiologyRespiratory systemOxidative phosphorylationCoronavirus disease 2019 (COVID-19)Function (biology)Lung functionMedicineCell biologyPathologyAnatomyInternal medicineBiochemistryInfectious disease (medical specialty)DiseaseSurgeryGenomics, phytochemicals, and oxidative stressVitamin C and Antioxidants ResearchSulfur Compounds in Biology