Inhibitors of Anti-apoptotic Bcl-2 Family Proteins Exhibit Potent and Broad-Spectrum Anti-mammarenavirus Activity via Cell Cycle Arrest at G0/G1 Phase
Yu-Jin Kim, Haydar Witwit, Beatrice Cubitt, Juan C. de la Torre
Abstract
Antiapoptotic Bcl-2 inhibitors have been shown to exert potent antiviral activities against various types of viruses via mechanisms that are currently poorly understood. This study has revealed that Bcl-2 inhibitors’ mediation of cell cycle arrest at the G0/G1 phase, rather than their proapoptotic activity, plays a critical role in blocking mammarenavirus multiplication in cultured cells.
Topics & Concepts
BiologyLymphocytic choriomeningitisCell cycleCell cycle checkpointSmall interfering RNAGene knockdownCell biologyViral life cycleCyclinRetinoblastoma proteinRNA interferenceCyclin-dependent kinaseKinaseCell Cycle ProteinVirusCell cultureMode of actionCancer researchG1 phaseRNACoronavirusCellCHEK1VirologyCyclin AViral replicationViral proteinCell growthCyclin B1Thymidine kinaseCyclin D1Animal Virus Infections StudiesPoxvirus research and outbreaksCell death mechanisms and regulation