Enhancement versus neutralization by SARS-CoV-2 antibodies from a convalescent donor associates with distinct epitopes on the RBD
Yunjiao Zhou, Zezhong Liu, Shibo Li, Wei Xu, Qianqian Zhang, Israel Tojal da Silva, Cheng Li, Yanling Wu, Qingling Jiang, Zhenmi Liu, Qiujing Wang, Yu Guo, Jianbo Wu, Chenjian Gu, Xia Cai, Di Qu, Christian T. Mayer, Xiangxi Wang, Shibo Jiang, Tianlei Ying, Zhenghong Yuan, Youhua Xie, Yumei Wen, Lu Lu, Qiao Wang
Abstract
(50% inhibitory concentration) values as low as 5.1 and 23.7 ng/mL, while not exhibiting ADE. Therefore, neutralization and ADE of human SARS-CoV-2 antibodies correlate with non-overlapping RBD epitopes.
Topics & Concepts
EpitopeAntibodyMonoclonal antibodyNeutralizationVirologyNeutralizing antibodyBiologyChemistryImmunologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing