Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
Paola Oliva, Romeo Romagnoli, Stefano Manfredini, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Roberto Ronca, Federica Maccarinelli, Arianna Giacomini, Fatlum Rruga, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi
Topics & Concepts
ChemistryStereochemistryFuranTubulinIn vivoSubstituentCombretastatinIn vitroBiological activityStructure–activity relationshipBiochemistryMicrotubuleOrganic chemistryBiotechnologyCell biologyBiologySynthesis and biological activityClick Chemistry and ApplicationsSynthesis of Organic Compounds