Functional validity, role, and implications of heavy alcohol consumption genetic loci
Andrew Thompson, James P. Cook, Hélène Choquet, Eric Jorgenson, Jie Yin, Tarja Kinnunen, Jeff W. Barclay, Andrew P. Morris, Munir Pirmohamed
Abstract
. Evidence of causal links to lung cancer, and shared genetic architecture with gout and hypertension was also found. These findings offer insight into genes, pathways, and relationships for disease risk associated with high alcohol consumption.
Topics & Concepts
ADH1BGeneticsGenetic architectureSNPBiologyGenome-wide association studyPopulationGenetic associationGeneComputational biologySingle-nucleotide polymorphismPhenotypeMedicineGenotypeEnvironmental healthDehydrogenaseBranched-chain alpha-keto acid dehydrogenase complexEnzymeBiochemistryAlcohol Consumption and Health EffectsPeroxisome Proliferator-Activated ReceptorsMetabolomics and Mass Spectrometry Studies