Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Miguel Manzano, María Vallet‐Regí
Abstract
Mesoporous Silica Nanoparticles (MSNs) represent a versatile platform in biomedicine thanks to their unique structural properties and functional versatility. These nanoparticles are at the forefront, offering exceptional biocompatibility, tunable pore sizes, and surface functionalization to enhance drug loading and controlled release. On top of that, stimuli-responsive MSNs can be designed to respond to specific triggers such as pH, temperature, or light. These smart MSNs further optimize drug delivery by ensuring targeted release and minimizing side effects. Beyond drug delivery applications, mesoporous materials are increasingly utilized in tissue regeneration, providing scaffolds that promote cell growth and integration. In bone-related pathologies, these materials exhibit significant potential, enhancing mineralization and facilitating the repair of osseous defects. Future perspectives focus on advancing the multifunctionality of MSNs, integrating imaging, therapeutic, and diagnostic capabilities into single platforms. The remarkable adaptability of MSNs ensures their continued evolution, paving the way for innovative solutions to complex biomedical challenges.