NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome
Michał Zarobkiewicz, Izabela Morawska, Adam Michalski, Jacek Roliński, Agnieszka Bojarska−Junak
Abstract
NKT cells comprise three subsets-type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an important cell subset in autoimmune diseases. In the current review, we are summarising results of NKT-oriented studies in major neurological autoimmune diseases-multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome and their corresponding animal models.
Topics & Concepts
Myasthenia gravisGuillain-Barre syndromeMultiple sclerosisImmunologyMedicineNatural killer T cellAutoimmunityT cellImmune systemImmune Cell Function and InteractionPeripheral Neuropathies and DisordersAutoimmune and Inflammatory Disorders Research