Synthetic routes to rhodanine scaffolds
Maryam Kargar, Ramin Javahershenas, Mehdi Adelzadeh, Massoud Ghobadi, Mosstafa Kazemi
Abstract
Rhodanine structural scaffolds are an important class of sulfur-containing heterocycles with a broad spectrum of applications in medicinal chemistry. Highly functionalized piperidine scaffolds have shown profound impact in drug discovery research owing to its important bioactivity. The green and high-yielding synthesis of rhodanine structural scaffolds from readily available materials remains is a hot topic research for the synthetic chemistry community. In this review, we discuss the recent various synthetic procedures reported in the literature for the synthesis of rhodanine structural scaffolds.
Topics & Concepts
RhodanineChemistryPiperidineCombinatorial chemistryDrug discoveryNanotechnologyOrganic chemistryBiochemistryMaterials scienceSulfur-Based Synthesis TechniquesMulticomponent Synthesis of HeterocyclesClick Chemistry and Applications