Near-infrared BODIPY photosensitizers for two-photon excited singlet oxygen generation and tumor cell photodynamic therapy
Ruibo Liu, Ying Qian
Abstract
-scanning method were 661.8 GM and 715.6 GM, respectively, and Cz-BDPI was further successfully applied to two-photon fluorescence imaging and two-photon excited singlet oxygen generation in zebrafish. The above results indicate that the introduction of aromatic heterocycles can effectively enhance the photodynamic efficacy of BODIPY photosensitizers, and the larger two-photon absorption cross section also brings potential for two-photon photodynamic therapy applications.
Topics & Concepts
Photodynamic therapySinglet oxygenPhotochemistryTwo-photon excitation microscopyBODIPYExcited statePhotosensitizerChemistryOxygenMaterials scienceFluorescenceOpticsPhysicsAtomic physicsOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials