Chemical modulation of Kv7 potassium channels
Matteo Borgini, Pravat Mondal, Ruiting Liu, Peter Wipf
Abstract
This review describes the synthetic and medicinal chemistry of small molecule modulators of the voltage-gated Kv7 (KCNQ) potassium channels and the available data of their biological and clinical properties.
Topics & Concepts
Potassium channelPotassiumModulation (music)ChemistryBiophysicsPhysicsBiologyAcousticsOrganic chemistryIon channel regulation and functionCardiac electrophysiology and arrhythmiasCoordination Chemistry and Organometallics