Structural basis of <i>Pseudomonas aeruginosa</i> penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol
Helen G. Smith, Shyam Basak, Victor Aniebok, Matthew J. Beech, Faisal M. Alshref, Mark D. Allen, Alistair J. M. Farley, Christopher J. Schofield
Abstract
The cephalosporin antibiotics cefiderocol, ceftazidime and cefepime undergo fragmentation on reaction with penicillin binding protein 3 from Pseudomonas aeruginosa.
Topics & Concepts
Pseudomonas aeruginosaSiderophorePenicillinMicrobiologyAntibioticsPseudomonasChemistryBiologyBacteriaGeneticsAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyBacterial biofilms and quorum sensing