Enterocyte superoxide dismutase 2 deletion drives obesity
Oihane García‐Irigoyen, Fabiola Bovenga, Marilidia Piglionica, Elena Piccinin, Marica Cariello, Maria Arconzo, Cláudia Maria Peres, Paola Antonia Corsetto, Angela Maria Rizzo, Marta Ballanti, Rossella Menghini, Geltrude Mingrone, Philippe Lefèbvre, Bart Staels, Takuji Shirasawa, Carlo Sabbà, Gaetano Villani, Massimo Federici, Antonio Moschetta
Abstract
Intestinal deletion of SOD2 drives spontaneous obesity and inflammation in mice SOD2 deficiency promotes phospholipase A2 activation and arachidonic acid release SOD2 ablation in enterocytes generates a pro-lipogenic phenotype Inverse relation between intestinal SOD2 and obesity features is present in humans
Topics & Concepts
SOD2Arachidonic acidSuperoxide dismutaseEndocrinologyInternal medicinePhospholipase A2Oxidative stressSOD1BiologyLipotoxicityInflammationPolyunsaturated fatty acidFatty acidChemistryBiochemistryMedicineEnzymeObesityInsulin resistanceMitochondrial Function and PathologyEicosanoids and Hypertension PharmacologyDiet and metabolism studies