Chemical sensors for imaging total cellular aliphatic aldehydes in live cells
Rachel Wills, Jonathan Farhi, Patrick Czabala, Sophia Allaf Shahin, Jennifer M. Spangle, Monika Raj
Abstract
), resulting in turn-on fluorescence. These sensors exhibit high quantum yields, high dynamic range, and enable the quantification of changes in both the exogenous administration of aldehydes and endogenous real-time formation of aliphatic aldehydes in live mammalian cells. This tool has great potential to transform aldehyde research by illuminating cellular metabolites that have remained elusive in living systems.
Topics & Concepts
Live cell imagingChemistryNanotechnologyMaterials scienceCellBiochemistryMolecular Sensors and Ion DetectionAdvanced Chemical Sensor TechnologiesAnalytical Chemistry and Sensors