Antibacterial Activity of an FtsZ Inhibitor Celastrol and Its Synergistic Effect with Vancomycin against Enterococci <i>In Vitro</i> and <i>In Vivo</i>
Xi Lü, Yanxiang Wang, Wei Guo, Zhimeng Zhang, Xinxin Hu, Tongying Nie, Xinyi Yang, Congran Li, Xiukun Wang, Xue Li, Yun Lu, Guoqing Li, Youwen Zhang, Lang Sun, Jing Pang, Xuefu You
Abstract
The emergence and transmission of VRE pose a significant medical and public health challenge. CEL, well-known for a wide range of biological activities, has not previously been investigated for its synergistic effect with vancomycin against VRE.
Topics & Concepts
VancomycinMicrobiologyFtsZIn vivoEnterococcus faeciumBiofilmEnterococcusIn vitroChemistryBiologyStaphylococcus aureusBacteriaAntibioticsBiochemistryCellCell divisionBiotechnologyGeneticsNatural Compounds in Disease TreatmentBioactive Compounds and Antitumor Agents